[Adaptation to hyperthermia and changes in peripheral blood leukocytes in humans]. / Adaptatsiia cheloveka k gipertermii i izmeneniia v leikotsitakh perifericheskoi krovi.

Heating humans up to rectal temperature 39.0-39.5 degrees C induces a heat stress and a physiological adaptation. Blood cells were found to produce nitric oxide under these conditions, neutrophiles playing a major role in the process. In our opinion, the HSC 70 takes part in the process of the long cell adaptation augmenting the cells' functional activity. Hyperthermia leads to a massive temporal HSP 72 expression in the blood mononuclears. This expression seems to be due to alterations in the cellular proteins and to oxidative stress.

[Effect of a short-term moderate whole body hyperthermia of healthy humans on their peripheral lymphocytes]. / Deistvie neprodolzhitel'nogo umerennogo nagrevaniia organizma zdorovogo cheloveka na perifericheskie limfotsity.

A short (75-110 min) mild (39.5 degrees C) whole body hyperthermia of humans does not alter the absolute amount of peripheral lymphocytes immediately after heating, but significantly reduces their relative amount due to neutrophil increase. Body heating does not induce lymphocyte degeneration: their potential viability does not reduce. The total level of lymphocyte oxidative metabolism remains unaltered, while SDG and LDG activities are seen reduced and increased, respectively. Lymphocytes adapt to body heating by inducing thermotolerant state and activating anaerobic metabolism.

[Aspects of healthy humans' response to hyperthermia]. / Osobennosti reaktsii organizma zdorovogo chekoveka na hipertermicheskoe vozdeistvie.

Single-shot hyperthermia of healthy young men in climate chamber up to rectal temperature of 39.5 degrees C over 75-110 minutes revealed variable heat resistance. Individuals with prevalent sympathetic vegetative regulation were more resistant to overheating, if compared to those with prevalent parasympathetic one. Endocrine group peculiarities were observed, the examinees with prevalent parasympathetic vegetative regulation demonstrated more drastic changes of some biochemical parameters.

[Clinical-physiological aspects of normobaric hypoxic training effects on functional status of patients with neurocirculatory dystonia]. / Kliniko-fiziologicheskie aspekty vliianiia normobaricheskoi gipoksicheskoi trenirovki na funktsional'noe sostoianie bol'nykh neirotsirkuliatornoi distoniei.

Profiles of external respiration and circulation, self-assessment of health, mental performance, sensory functions, and peripheral blood were studied in patients with neurocirculatory dystonia in the course of normobaric hypoxic training. The hypoxic training proved to successfully normalize arterial pressure, eliminate cardiac arrhythmias, and benefit general condition. Substantial strengthening of hypoxic resistance was stated along with an oxygen debt reduction during hypoxia, improvement of sensory coordination and mental performance, and activation of erythropoiesis.

[Methodological aspects and clinicophysiological substantiation of applying the hypoxic therapy]. / Metodologicheskie aspekty i kliniko-fiziologicheskoe obosnovanie primeneniia gipoksiterapii.

The paper gives the methodical and clinicophysiological substantiation of the hypoxic therapy, a new nonmedicamentous method of body sanitation, raising its physiological reserves, prevention of pathological states, treatment and medical rehabilitation of patients based on breathing air with a reduced O2 partial pressure for the purposes. Health damaging and improving effects of hypoxic hypoxia, perspectives of this therapy from the standpoint of prevention and treatment of myocardial ischemia are discussed. Results of the fundamental studies unveiling the mechanisms of ischemic, reperfusion-induced disorders of myocardium and assessing possibilities of their blockage of the hypoxic therapy are considered. On the literary and own evidence, the authors analyse effectiveness, merits and drawbacks of different (mountain/climatic, hypobaric, normobaric) techniques of hypoxic therapy. Informative criteria for determination of hypoxic resistance of the patient with coronary diseases and choice of individual hypoxic regimen are rationalized.

[Immuno-physiological and hematological aspects of flight certification examination]. / Immunofiziologicheskie i gematologicheskie aspekty vrachebno-letnoi ekspertizy.

Revision of immunophysiological and hematological approaches to medical examination of flight personnel is the focus of this paper. Basing on literary data and results of their own investigations, the authors demonstrate the linkage between occupational impacts on flyers and alterations in the function of specific and non-specific body defense systems. Potential areas for updating flight certification examination procedure, i.e. development of flyers blood and resistance data bank, elaboration of objective immunophysiological and hematological criteria for assessing body response to standard functional tests, comprehensive evaluation of human reaction to exogenic agents and delineation of patterns of correlation between blood and anti-body indices, and other body systems.

[Patterns of the changes in the indices of B-system immunity in acute psychoemotional stress]. / Zakonomernosti izmenenii pokazatelei B-sistemy immuniteta pri ostrom psikhoémotsional'nom napriazhenii.

Psychoemotional stress induces in healthy individuals increased serum Ig and C3 subunit of complement. Response of B immunity psychoemotional stress remains within the limits of basic functioning. State of B immunity in psychologic comfort condition insignificantly depends on individual psychology. Uniqueness on individual immune reactions in psychoemotional stress presents depression of reserved B lymphocytes, which could be easily seen in people of controversial personality type.

[The psychophysiological characteristics and correction of extreme states of an informational-semantic origin]. / Psikhofiziologicheskaia kharakteristika i korrektsiia ékstremal'nykh sostoianii informatsionno-semanticheskogo geneza.

The article deals with the general characteristics of extreme states influence. The authors systematize the factors which may be considered as extreme ones. The article shows that the development of different extreme states frequently is predetermined by informative-semantic nature. The following types of extreme states of informative-semantic genesis were studied: emotional tension, anxiety, fear, affective excitement, inhibition, depersonalization. There are psychophysiological characteristics of these states and basic methods of its correction.

[Specific features of humoral immunity and nonspecific resistance in pilots]. / Nekotorye osobennosti gumoral'nogo immuniteta i nespetsificheskoi rezistentnosti u letchikov.

Immune responses of the flying personnel to adverse flight effects were investigated. Altogether 134 pilots in the age of 22 to 42 years were examined. A significant decline of IgA, IgM, IgG, C3, alpha-antitrypsin, and R-proteins was found. Correlation analysis of over 100 anthropometric, psychophysiological, immune parameters as well as questionnaire data helped identify correlates and develop mathematical models which included IgA and IgM as parameters. Analysis shows that there is a relationship between personality features and humoral immunity of pilots: emotional strain increases, emotional stability decreases while immunoglobulins decline. In response to flight effects, changes in physiological functions, personality features, humoral immunity, and nonspecific resistance were interrelated.

[Relations between the indicators of humoral immunity and psychological adaptation of pilots]. / O vzaimoornosheniiakh pokazatelei gumoral'nogo immuniteta i psikhicheskoi adaptatsii u letchikov.

Peripheral blood serum A, M and G immunoglobulins were measured in 123 pilots, 22 to 42 years of age, distributed in groups as to the degree of frustrational tension (FT), related frustrational tension (RFT) and frustrational intolerance (FI). Inverse correlation was found between the indices of psychic adaptation (FT, RFT and FI) and the M immunoglobulin content. No evident correlation was traced between the levels of the circulating A and G immunoglobulins and the psychological peculiarities assessed in the pilots.